A facile synthesis of a novel family of heterotricyclic hybrids: Spiro-pyrrolopyridazines

An efficient strategy for the synthesis of spiro-pyrrolopyridazines has been developed. When reacted with hydrazine monohydrate, spiro-2H-pyrroles a 1,4-diketone functionality produced novel family heterotricyclic hybrids, spiro-pyrrolopyridazines, specifically spiro{cyclohexane-1,5'-pyrrolo[3,4-d]pyridazine} systems. The condensation reaction monohydrate in refluxing 1-butanol proceeded well and afforded good to high yields. was found be general variety demonstrated tolerance aromatic heteroaromatic groups electron-withdrawing electron-donating substituents. spiro-pyrrolopyridazine hybrids may exhibit potential deliver diverse structural motifs that aid drug discovery efforts.